I'm playing the PC version, which has some small graphical issues, somewhat, in that textures can occasionally load slower than normal. I suspect my system is to blame(I'm in between the recommended and the min requirements). I also discovered a bug in which if you have a TV in your settlement that is powered, the resource/bed numbers as well as the settlement population gets artificially screwy and the settlement happiness takes a plummet even if you have enough defense for the food/water and enough beds for people to sleep in. I suspect the same glitch can also prevent settlements from properly growing.
They are releasing some fixes already, though, the first beta patch they released on day one fixed a crash issue, and the upcoming version fixes performance issues at Corvega assembly, which is an important location for expanding your settlement control(which is vital for high charisma characters, population is power). You also have to account for mods that were already coming out even before official mod support was released.
Other than those issues though, I found the game to be pretty stable for the most part. It'll sometimes get stuck in loading or crash after like 4-5 hours of play, but often thats more when I need to take a break anyways.
I agree with Taceus Jiwede on difficulty, fallout 4 is a game where being a high level with even half smart perk choices can make the game very easy on any difficulty setting. What I mean by artificial difficulty though is where for example, in fallout 3 every single enemy became an albino radscorpion/overlord/ferel ghoul reaver while every enemy in point lookout blantly cheated with +35 damage ignoring armor per hit on weapons that only applied to the AI. Generally Fallout 4 has it's moments, but it's nothing severe or frequent. In fact some of the worst case scenarios(raiders in power armor with a fatman) are somewhat telegraphed and only tend to happen once, most of the time(not to mention, enemies with missiles and mini nukes CAN run out of ammo).
My last character before I scrapped her got as high as level 60(the newest one will get higher) and I even made the poor decision to switch from pistols to rifles when I could have just started with rifles. And I switched in the mid 30s on her and probably did not need to and could have gone with demolition expert instead. I also had idiot savant(a perk I regretted using from leveling TO fast) and toughness(one of the weakest long-term perks thats made specifically to make the early levels easier) and found the late game to be easy simply due to my equipment being very good. So you cannot really go wrong with how you develop your character unless you deliberately try to do stupid things.
Thank you for your review Alex. Are you playing the PC or Console version? I'm a PC gamer--I know console gaming is cool, but it's just not my thing. Bethesda has major issues porting their console games to PC. It's like they are actively discouraging PC gamers from playing their games the interface conversion from console to PC is so poor. I've heard bad things about Fallout 4 in this regard. What is your opinion?