I think making the attack a car bomb is already a big mistake. In the original, that was a very PERSONAL death. Murphy was isolated, beaten down, and tortured, the leering faces of his attackers all around him, laughing at him as he screamed in agony. We felt for Murphy. When he was finally shot in the head to end it, it was almost a mercy-killing. In this, he opens his car door, and boom, it's all over. Removing that personal element is a big factor.
Imagine if, for example, they made a Batman origin movie where Bruce's parents weren't shot by a mugger, but were instead killed when a bank robber, fleeing the police in his getaway vehicle, sideswiped a truck that hit a building that knocked some masonry loose, which then fell on Bruce's parents. Sure, a criminal still killed Bruce's parents, but not in the same personal way. THAT'S what this feels like.
And that's just one tiny aspect. The new Robocop appears to still be alive, rather than dead, so he's not OCP's (or whatever they're calling it) "property". He's still Alex J. Murphy, only with fancy life support armor (a la Darth Vader). And with his family knowing that he's Robocop, that whole angle of him losing them is gone, too.
Finally, the armor looks very flimsy and weightless. The original movie made his new body as much of a curse as a blessing (as it was very strong, accurate, and durable, but also very heavy, bulky, slow, and obviously inhuman), while this one shows RoboCop running right from the start.
(ED-209 I can forgive. It's impracticably designed, but that's always been the point. Heck, in the original film it was a robotic security guard that couldn't climb stairs, or get up after it had fallen. That's not a practical design)
I know it's just an early trailer, but even from that I can see that the changes aren't minor. It just feels like they wanted to make an entirely different movie, but then the studio slapped the Robocop name onto it because they saw some superficial similarities.