You know you've played too much CoH when you have a hard time not calling a villain's influence (in another game or even in a book) "infamy."
You know you've played too much CoH when you think of characters in other games as hero, villain, vigilante, or rogue.
(Just posting this for fun! I'm looking forward to seeing what other people say "you know you've played too much CoH when..." And yes, I did do both of the things I posted.)